Ontology highlight
ABSTRACT:
SUBMITTER: Guler GD
PROVIDER: S-EPMC3307258 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Guler Gulfem Dilek GD Liu Hanjian H Vaithiyalingam Sivaraja S Arnett Diana R DR Kremmer Elisabeth E Chazin Walter J WJ Fanning Ellen E
The Journal of biological chemistry 20111221 9
Maintenance of genomic stability in proliferating cells depends on a network of proteins that coordinate chromosomal replication with DNA damage responses. Human DNA helicase B (HELB or HDHB) has been implicated in chromosomal replication, but its role in this coordinated network remains undefined. Here we report that cellular exposure to UV irradiation, camptothecin, or hydroxyurea induces accumulation of HDHB on chromatin in a dose- and time-dependent manner, preferentially in S phase cells. R ...[more]