Ontology highlight
ABSTRACT:
SUBMITTER: Luo W
PROVIDER: S-EPMC3307393 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Cell 20120202 4
Although molecular components of the circadian clock are known, mechanisms that transmit signals from the clock and produce rhythmic behavior are poorly understood. We find that the microRNA miR-279 regulates the JAK/STAT pathway to drive rest:activity rhythms in Drosophila. Overexpression of microRNA miR-279 or miR-279 deletion attenuates rest:activity rhythms. Oscillations of the clock protein PERIOD are normal in pacemaker neurons lacking miR-279, suggesting that miR-279 acts downstream of th ...[more]