Ontology highlight
ABSTRACT:
SUBMITTER: Congreve M
PROVIDER: S-EPMC3308197 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20120127 5
Potent, ligand efficient, selective, and orally efficacious 1,2,4-triazine derivatives have been identified using structure based drug design approaches as antagonists of the adenosine A(2A) receptor. The X-ray crystal structures of compounds 4e and 4g bound to the GPCR illustrate that the molecules bind deeply inside the orthosteric binding cavity. In vivo pharmacokinetic and efficacy data for compound 4k are presented, demonstrating the potential of this series of compounds for the treatment o ...[more]