Ontology highlight
ABSTRACT:
SUBMITTER: Moyle-Heyrman G
PROVIDER: S-EPMC3308732 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Moyle-Heyrman Georgette G Viswanathan Ramya R Widom Jonathan J Auble David T DT
The Journal of biological chemistry 20120201 12
The TATA box binding protein (TBP) is a central component of the transcription preinitiation complex, and its occupancy at a promoter is correlated with transcription levels. The TBP-promoter DNA complex contains sharply bent DNA and its interaction lifetime is limited by the ATP-dependent TBP displacement activity of the Snf2/Swi2 ATPase Mot1. Several mechanisms for Mot1 action have been proposed, but how it catalyzes TBP removal from DNA is unknown. To better understand the Mot1 mechanism, nat ...[more]