Ontology highlight
ABSTRACT:
SUBMITTER: Charlop-Powers Z
PROVIDER: S-EPMC3308761 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Charlop-Powers Zachary Z Jakoncic Jean J Gurnon James R JR Van Etten James L JL Zhou Ming-Ming MM
The Journal of biological chemistry 20120125 12
Paramecium bursaria chlorella virus 1 (PBCV-1), a large DNA virus that infects green algae, encodes a histone H3 lysine 27-specific methyltransferase that functions in global transcriptional silencing of the host. PBCV-1 has another gene a654l that encodes a protein with sequence similarity to the GCN5 family histone acetyltransferases. In this study, we report a 1.5 Å crystal structure of PBCV-1 A654L in a complex with coenzyme A. The structure reveals a unique feature of A654L that precludes i ...[more]