Ontology highlight
ABSTRACT:
SUBMITTER: Chen CH
PROVIDER: S-EPMC3308990 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Chen Chia-Hsin CH Chu Po-Chen PC Lee Liekyeow L Lien Huang-Wei HW Lin Tse-Ling TL Fan Chi-Chen CC Chi Peter P Huang Chang-Jen CJ Chang Mau-Sun MS
PloS one 20120320 3
Human p29 is a putative component of spliceosomes, but its role in pre-mRNA is elusive. By siRNA knockdown and stable overexpression, we demonstrated that human p29 is involved in DNA damage response and Fanconi anemia pathway in cultured cells. In this study, we generated p29 knockout mice (mp29(GT/GT)) using the mp29 gene trap embryonic stem cells to study the role of mp29 in DNA damage response in vivo. Interruption of mp29 at both alleles resulted in embryonic lethality. Embryonic abnormalit ...[more]