Supramolecular host-guest interaction for labeling and detection of cellular biomarkers.
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ABSTRACT:
SUBMITTER: Agasti SS
PROVIDER: S-EPMC3309171 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Supramolecular host-guest interaction for labeling and detection of cellular biomarkers.
Agasti Sarit S SS Liong Monty M Tassa Carlos C Chung Hyun Jung HJ Shaw Stanley Y SY Lee Hakho H Weissleder Ralph R
Angewandte Chemie (International ed. in English) 20111124 2
Be my guest: A supramolecular host-guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting. ...[more]
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