Ontology highlight
ABSTRACT:
SUBMITTER: Kondilis-Mangum HD
PROVIDER: S-EPMC3309396 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Kondilis-Mangum Hrisavgi D HD Shih Han-Yu HY Mahowald Grace G Sleckman Barry P BP Krangel Michael S MS
Journal of immunology (Baltimore, Md. : 1950) 20111111 12
Ag receptor loci are regulated to promote allelic exclusion, but the mechanisms are not well understood. Assembly of a functional TCR β-chain gene triggers feedback inhibition of V(β)-to-DJ(β) recombination in double-positive (DP) thymocytes, which correlates with reduced V(β) chromatin accessibility and a locus conformational change that separates V(β) from DJ(β) gene segments. We previously generated a Tcrb allele that maintained V(β) accessibility but was still subject to feedback inhibition ...[more]