Ontology highlight
ABSTRACT:
SUBMITTER: Briegel A
PROVIDER: S-EPMC3309718 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Briegel Ariane A Li Xiaoxiao X Bilwes Alexandrine M AM Hughes Kelly T KT Jensen Grant J GJ Crane Brian R BR
Proceedings of the National Academy of Sciences of the United States of America 20120221 10
Chemoreceptor arrays are supramolecular transmembrane machines of unknown structure that allow bacteria to sense their surroundings and respond by chemotaxis. We have combined X-ray crystallography of purified proteins with electron cryotomography of native arrays inside cells to reveal the arrangement of the component transmembrane receptors, histidine kinases (CheA) and CheW coupling proteins. Trimers of receptor dimers lie at the vertices of a hexagonal lattice in a "two-facing-two" configura ...[more]