Adenosine kinase inhibition selectively promotes rodent and porcine islet ?-cell replication.
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ABSTRACT:
SUBMITTER: Annes JP
PROVIDER: S-EPMC3309788 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
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Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication.
Annes Justin P JP Ryu Jennifer Hyoje JH Lam Kelvin K Carolan Peter J PJ Utz Katrina K Hollister-Lock Jennifer J Arvanites Anthony C AC Rubin Lee L LL Weir Gordon G Melton Douglas A DA
Proceedings of the National Academy of Sciences of the United States of America 20120215 10
Diabetes is a pathological condition characterized by relative insulin deficiency, persistent hyperglycemia, and, consequently, diffuse micro- and macrovascular disease. One therapeutic strategy is to amplify insulin-secretion capacity by increasing the number of the insulin-producing β cells without triggering a generalized proliferative response. Here, we present the development of a small-molecule screening platform for the identification of molecules that increase β-cell replication. Using t ...[more]
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