Ontology highlight
ABSTRACT:
SUBMITTER: Wei W
PROVIDER: S-EPMC3310198 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Wei Wei W Nguyen Louis N LN Kessels Helmut W HW Hagiwara Hiroaki H Sisodia Sangram S Malinow Roberto R
Nature neuroscience 20091227 2
Excessive synaptic loss is thought to be one of the earliest events in Alzheimer's disease. Amyloid beta (Abeta), a peptide secreted in an activity-modulated manner by neurons, has been implicated in the pathogenesis of Alzheimer's disease by removing dendritic spines, sites of excitatory synaptic transmission. However, issues regarding the subcellular source of Abeta, as well as the mechanisms of its production and actions that lead to synaptic loss, remain poorly understood. In rat organotypic ...[more]