Ontology highlight
ABSTRACT:
SUBMITTER: Shan J
PROVIDER: S-EPMC3310947 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Shan Jufang J Zhang Xinxin X Bao Ju J Cassell Robert R Zheng Jie J JJ
Chemical biology & drug design 20120130 4
Dishevelled (Dvl) PDZ domains transduce Wnt signals from the membrane-bound receptor Frizzled to the downstream. As abnormal Wnt signaling has been implicated in tumorigenesis, the Dvl PDZ domain is a potential target for small-molecule inhibitors that block Wnt signaling at the Dvl level. We expanded our in silico search to examine the chemical space near previously developed PDZ binders and identified nine additional compounds bind to the Dvl PDZ. We then performed a quantitative structure-act ...[more]