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Molecular epidemiology of Rift Valley fever virus.

ABSTRACT: Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was a reassortant. The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed.

SUBMITTER: Grobbelaar AA

PROVIDER: S-EPMC3311189 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Molecular epidemiology of Rift Valley fever virus.

Grobbelaar Antoinette A AA Weyer Jacqueline J Leman Patricia A PA Kemp Alan A Paweska Janusz T JT Swanepoel Robert R

Emerging infectious diseases 20111201 12

Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was ...[more]

PMID: 22172568

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2021-10-22 | GSE186067 | GEO

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