Ontology highlight
ABSTRACT:
SUBMITTER: Meer EJ
PROVIDER: S-EPMC3311331 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Meer Elliott J EJ Wang Dan Ohtan DO Kim Sangmok S Barr Ian I Guo Feng F Martin Kelsey C KC
Proceedings of the National Academy of Sciences of the United States of America 20120301 12
Messenger RNA (mRNA) localization and regulated translation can spatially restrict gene expression to each of the thousands of synaptic compartments formed by a single neuron. Although cis-acting RNA elements have been shown to direct localization of mRNAs from the soma into neuronal processes, less is known about signals that target transcripts specifically to synapses. In Aplysia sensory-motor neuronal cultures, synapse formation rapidly redistributes the mRNA encoding the peptide neurotransmi ...[more]