Ontology highlight
ABSTRACT:
SUBMITTER: Han L
PROVIDER: S-EPMC3311337 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Han Li L Mao Weifeng W Yu Kefei K
Proceedings of the National Academy of Sciences of the United States of America 20120305 12
DNA double-strand breaks (DSBs) are essential intermediates in Ig gene rearrangements: V(D)J and class switch recombination (CSR). In contrast to V(D)J recombination, which is almost exclusively dependent on nonhomologous end joining (NHEJ), CSR can occur in NHEJ-deficient cells via a poorly understand backup pathway (or pathways) often termed alternative end joining (A-EJ). Recently, several components of the single-strand DNA break (SSB) repair machinery, including XRCC1, have been implicated ...[more]