Ontology highlight
ABSTRACT:
SUBMITTER: Blonska M
PROVIDER: S-EPMC3311756 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Blonska Marzenna M Joo Donghyun D Zweidler-McKay Patrick A PA Zhao Qingyu Q Lin Xin X
Journal of immunology (Baltimore, Md. : 1950) 20120227 7
The scaffold protein CARMA1 is required for the TCR-induced lymphocyte activation. In this study, we show that CARMA1 also plays an essential role in T cell differentiation. We have found that the adoptive transfer of bone marrow cells expressing constitutively active CARMA1 results in lung inflammation, eosinophilia, and elevated levels of IL-4, IL-5, and IL-10 in recipient mice. In contrast, CARMA1-deficient T cells are defective in TCR-induced expression of Th2 cytokines, suggesting that CARM ...[more]