Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
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ABSTRACT:
SUBMITTER: Cedeno-Laurent F
PROVIDER: S-EPMC3311782 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
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Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression.
Cedeno-Laurent Filiberto F Opperman Matthew M Barthel Steven R SR Kuchroo Vijay K VK Dimitroff Charles J CJ
Journal of immunology (Baltimore, Md. : 1950) 20120217 7
Galectin-1 (Gal-1), a β-galactoside-binding protein, can alter fate and effector function of Th cells; however, little is known about how Gal-1 induces Th cell differentiation. In this article, we show that both uncommitted and polarized Th cells bound by Gal-1 expressed an immunoregulatory signature defined by IL-10. IL-10 synthesis was stimulated by direct Gal-1 engagement to cell surface glycoproteins, principally CD45, on activated Th cells and enhanced by IL-21 expression through the c-Maf/ ...[more]
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