Ontology highlight
ABSTRACT:
SUBMITTER: Gruzdev A
PROVIDER: S-EPMC3312001 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Gruzdev Artiom A Nguyen MyTrang M Kovarova Martina M Koller Beverly H BH
Prostaglandins & other lipid mediators 20120211 3-4
The ductus arteriosus (DA) is a fetal shunt that directs right ventricular outflow away from pulmonary circulation and into the aorta. Critical roles for prostaglandin E(2) (PGE(2)) and the EP4 receptor (EP4) have been established in maintaining both the patency of the vessel in utero and in its closure at birth. Here we have generated mice in which loss of EP4 expression is limited to either the smooth muscle (SMC) or endothelial cells and demonstrated that SMC, but not endothelial cell express ...[more]