SERPINB13 is a novel RUNX1 target gene.
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ABSTRACT:
SUBMITTER: Boyapati A
PROVIDER: S-EPMC3312028 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
SERPINB13 is a novel RUNX1 target gene.
Boyapati Anita A Ren Bing B Zhang Dong-Er DE
Biochemical and biophysical research communications 20110623 1
RUNX1 is a critical transcription factor during embryogenesis and neoplastic disease. To identify novel transcriptional targets of RUNX1 in the context of chromatin, we performed genome wide location analysis (ChIP-on-chip). Here we report that SERPINB13, a gene downregulated in head and neck cancers, is a novel RUNX1transcriptional target. RUNX1 binds the SERPINB13 promoter in chromatin to repress its transcription. Mutation of either RUNX1 binding site in the SERPINB13 promoter increased the a ...[more]
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