Adsorption and desorption of bioactive proteins on hydroxyapatite for protein delivery systems.
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ABSTRACT:
SUBMITTER: Kojima C
PROVIDER: S-EPMC3312276 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Adsorption and desorption of bioactive proteins on hydroxyapatite for protein delivery systems.
Kojima Chie C Watanabe Kenji K
Journal of drug delivery 20120305
Hydroxyapatite (HA) is a precursor of bone and has been studied as a biomaterial. We attempted HA to apply to protein delivery systems. In this study, the association and dissociation properties of two types of bioactive proteins, cytochrom c and insulin, to HA were investigated. Cytochrom c was less associated with HA than insulin, which was easily released from it. However, the release of insulin from HA was slow. Insulin was released from HA at pH 7.4 more rapidly than at pH 3. The associatio ...[more]
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