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The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.

ABSTRACT: The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, which may underlie pathogenesis of mood and anxiety disorders.

SUBMITTER: Liu F 

PROVIDER: S-EPMC3312460 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.

Liu Feng F   Havens Jennifer J   Yu Qi Q   Wang Gang G   Davisson Robin L RL   Pickel Virginia M VM   Iadecola Costantino C  

International journal of physiology, pathophysiology and pharmacology 20120215 1

The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, whic  ...[more]

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