Ontology highlight
ABSTRACT:
SUBMITTER: Vis DJ
PROVIDER: S-EPMC3312884 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Vis Daniel J DJ Westerhuis Johan A JA Hoefsloot Huub C J HC Roelfsema Ferdinand F Hendriks Margriet M W B MM Smilde Age K AK
PloS one 20120326 3
The regulatory mechanisms underlying pulsatile secretion are complex, especially as it is partly controlled by other hormones and the combined action of multiple agents. Regulatory relations between hormones are not directly observable but may be deduced from time series measurements of plasma hormone concentrations. Variation in plasma hormone levels are the resultant of secretion and clearance from the circulation. A strategy is proposed to extract inhibition, activation, thresholds and circad ...[more]