Synthesis of azaphilone-based chemical libraries.
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ABSTRACT:
SUBMITTER: Achard M
PROVIDER: S-EPMC3313624 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Synthesis of azaphilone-based chemical libraries.
Achard Mathieu M Beeler Aaron B AB Porco John A JA
ACS combinatorial science 20120224 3
The synthesis of azaphilone scaffolds that have been further diversified by cross coupling acylation and amine addition is reported. Methodology development also led to novel modifications including C5 acetoxylation and condensations producing isoquinolin-6(7H) structures. Overall, the library synthesis afforded three azaphilone sublibraries, including vinylogous pyridones which project diversity elements in four sectors of the azaphilone core. ...[more]
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