Ontology highlight
ABSTRACT:
SUBMITTER: Zoldan J
PROVIDER: S-EPMC3313669 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Zoldan Janet J Karagiannis Emmanouil D ED Lee Christopher Y CY Anderson Daniel G DG Langer Robert R Levenberg Shulamit S
Biomaterials 20111001 36
Mechanical forces are critical to embryogenesis, specifically, in the lineage-specification gastrulation phase, whereupon the embryo is transformed from a simple spherical ball of cells to a multi-layered organism, containing properly organized endoderm, mesoderm, and ectoderm germ layers. Several reports have proposed that such directed and coordinated movements of large cell collectives are driven by cellular responses to cell deformations and cell-generated forces. To better understand these ...[more]