Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki O
PROVIDER: S-EPMC3313694 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Proceedings of the Japan Academy. Series B, Physical and biological sciences 20110101 8
Sugar chain abnormalities in glycolipids and glycoproteins are associated with various diseases. Here, we report an adult onset cardiac dilatation in a transgenic mouse line with Galβ1,3GalNAc α2,3-sialyltransferase II (ST3Gal-II) transgenes. The transgenic hearts at the end-stage, at around 7 months old, were enlarged, with enlarged cavities and thin, low-tensile walls, typical of dilated cardiomyopathy. Although no apparent change was found in heart gangliosides, glycosylation of heart protein ...[more]