Ontology highlight
ABSTRACT:
SUBMITTER: Chung S
PROVIDER: S-EPMC3313695 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Chung Suyoun S Nakashima Mitsuko M Zembutsu Hitoshi H Nakamura Yusuke Y
Proceedings of the Japan Academy. Series B, Physical and biological sciences 20110101 8
Keloid represents overgrowth of granulation tissue, which is characterized by collection of atypical fibroblasts with excessive deposition of extracellular matrix components, after skin injury, but its etiology is still largely unknown. We recently performed genome-wide association study (GWAS) of keloid and identified NEDD4 to be one of candidate molecules associated with keloid susceptibility. Here we demonstrate a possible mechanism of NEDD4 involvement in keloid formation through enhancement ...[more]