Ontology highlight
ABSTRACT:
SUBMITTER: Kanno Y
PROVIDER: S-EPMC3314163 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Annual review of immunology 20120106
T helper cell differentiation occurs in the context of the extracellular cytokine milieu evoked by diverse microbes and other pathogenic stimuli along with T cell receptor stimulation. The culmination of these signals results in specification of T helper lineages, which occurs through the combinatorial action of multiple transcription factors that establish distinctive transcriptomes. In this manner, inducible, but constitutively active, master regulators work in conjunction with factors such as ...[more]