Ontology highlight
ABSTRACT:
SUBMITTER: Singh R
PROVIDER: S-EPMC3314179 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Singh Reena R Hoogaars Willem M WM Barnett Phil P Grieskamp Thomas T Rana M Sameer MS Buermans Henk H Farin Henner F HF Petry Marianne M Heallen Todd T Martin James F JF Moorman Antoon F M AF 't Hoen Peter A C PA Kispert Andreas A Christoffels Vincent M VM
Cellular and molecular life sciences : CMLS 20111201 8
A key step in heart development is the coordinated development of the atrioventricular canal (AVC), the constriction between the atria and ventricles that electrically and physically separates the chambers, and the development of the atrioventricular valves that ensure unidirectional blood flow. Using knock-out and inducible overexpression mouse models, we provide evidence that the developmentally important T-box factors Tbx2 and Tbx3, in a functionally redundant manner, maintain the AVC myocard ...[more]