Unknown

Dataset Information

0

Copper-catalyzed enantioselective intramolecular alkene amination/intermolecular Heck-type coupling cascade.

ABSTRACT: Enantioselective copper-catalyzed cyclization of ?-alkenylsulfonamides and a ?-alkenylsulfonamide in the presence of a range of vinyl arenes results in variously functionalized 2-substituted chiral nitrogen heterocycles via a formal alkene C-H functionalization process. Application of this reaction to the concise synthesis of a 5-HT(7) receptor antagonist is demonstrated.

SUBMITTER: Liwosz TW 

PROVIDER: S-EPMC3314298 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Copper-catalyzed enantioselective intramolecular alkene amination/intermolecular Heck-type coupling cascade.

Liwosz Timothy W TW   Chemler Sherry R SR  

Journal of the American Chemical Society 20120124 4

Enantioselective copper-catalyzed cyclization of γ-alkenylsulfonamides and a δ-alkenylsulfonamide in the presence of a range of vinyl arenes results in variously functionalized 2-substituted chiral nitrogen heterocycles via a formal alkene C-H functionalization process. Application of this reaction to the concise synthesis of a 5-HT(7) receptor antagonist is demonstrated. ...[more]

Similar Datasets

Unknown Chiral Indoline Synthesis Via Enantioselective Intramolecular Copper-Catalyzed Alkene Hydroamination.
| S-EPMC3519432 | biostudies-literature
Unknown Mechanistic analysis and optimization of the copper-catalyzed enantioselective intramolecular alkene aminooxygenation.
| S-EPMC3697020 | biostudies-literature
Unknown Copper catalyzed enantioselective intramolecular aminooxygenation of alkenes.
| S-EPMC2674573 | biostudies-literature
Unknown 6-Azabicyclo[3.2.1]octanes Via Copper-Catalyzed Enantioselective Alkene Carboamination.
| S-EPMC4254729 | biostudies-literature
Unknown Direct Oxidation of Aryl Malononitriles Enabling a Copper-Catalyzed Intermolecular Alkene Carbochlorination.
| S-EPMC7885264 | biostudies-literature
Unknown Enantioselective Intermolecular Radical C-H Amination.
| S-EPMC7726091 | biostudies-literature
Unknown Palladium-Catalyzed Enantioselective Intermolecular Coupling of Phenols and Allylic Alcohols.
| S-EPMC5180452 | biostudies-literature
Unknown Mechanistic Model for Enantioselective Intramolecular Alkene Cyanoamidation via Palladium-Catalyzed C-CN Bond Activation.
| S-EPMC5535300 | biostudies-literature
Unknown Copper-catalyzed intramolecular alkene carboetherification: synthesis of fused-ring and bridged-ring tetrahydrofurans.
| S-EPMC3430129 | biostudies-literature
Unknown Enantioselective, Aerobic Copper-Catalyzed Intramolecular Carboamination and Carboetherification of Unactivated Alkenes.
| S-EPMC8293922 | biostudies-literature