Dissecting the kinetic process of amyloid fiber formation through asymptotic analysis.
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ABSTRACT:
SUBMITTER: Hong L
PROVIDER: S-EPMC3314729 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Dissecting the kinetic process of amyloid fiber formation through asymptotic analysis.
Hong Liu L Qi Xianghong X Zhang Yang Y
The journal of physical chemistry. B 20111213 23
Amyloids are insoluble fibrous protein aggregates which, when abnormally accumulated in the body, can result in amyloidosis and various neurodegenerative diseases. In this work, we describe a new approach to the asymptotic solution of the master equation of amyloid fiber aggregations. It is found that four distinct and successive stages (lag phase, exponential growth phase, breaking phase, and static phase) dominate the fiber formation process. On the basis of the distinctive power-law dependenc ...[more]
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