Ontology highlight
ABSTRACT:
SUBMITTER: Waga S
PROVIDER: S-EPMC33149 | biostudies-literature | 2001 Apr
REPOSITORIES: biostudies-literature
Waga S S Masuda T T Takisawa H H Sugino A A
Proceedings of the National Academy of Sciences of the United States of America 20010410 9
DNA polymerase epsilon (Pol epsilon) is thought to be involved in DNA replication, repair, and cell-cycle checkpoint control in eukaryotic cells. Although the requirement of other replicative DNA polymerases, DNA polymerases alpha and delta (Pol alpha and delta), for chromosomal DNA replication has been well documented by genetic and biochemical studies, the precise role, if any, of Pol epsilon in chromosomal DNA replication is still obscure. Here we show, with the use of a cell-free replication ...[more]