Ontology highlight
ABSTRACT:
SUBMITTER: Lettice LA
PROVIDER: S-EPMC3314984 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Lettice Laura A LA Williamson Iain I Wiltshire John H JH Peluso Silvia S Devenney Paul S PS Hill Alison E AE Essafi Abdelkader A Hagman James J Mort Richard R Grimes Graeme G DeAngelis Carlo L CL Hill Robert E RE
Developmental cell 20120201 2
Sonic hedgehog (Shh) expression during limb development is crucial for specifying the identity and number of digits. The spatial pattern of Shh expression is restricted to a region called the zone of polarizing activity (ZPA), and this expression is controlled from a long distance by the cis-regulator ZRS. Here, members of two groups of ETS transcription factors are shown to act directly at the ZRS mediating a differential effect on Shh, defining its spatial expression pattern. Occupancy at mult ...[more]