Ontology highlight
ABSTRACT:
SUBMITTER: Chan TO
PROVIDER: S-EPMC3315091 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Chan Tung O TO Pascal John M JM Armen Roger S RS Rodeck Ulrich U
Cell cycle (Georgetown, Tex.) 20120201 3
AGC kinases, including the three Akt (protein kinase B) isoforms, protein kinase A (PKA) and all protein kinase C (PKC) isoforms, require activation loop phosphorylation (threonine 308 in Akt1) as well as phosphorylation of a C-terminal residue (serine 473 in Akt1) for catalytic activity and phosphorylation of downstream targets. Conversely, phosphatases reverse these phosphorylations. Virtually all cellular processes are affected by AGC kinases, a circumstance that has led to intense scrutiny o ...[more]