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Transcription co-activator SAYP mediates the action of STAT activator.

ABSTRACT: Jak/STAT is an important signaling pathway mediating multiple events in development. We describe participation of metazoan co-activator SAYP/PHF10 in this pathway downstream of STAT. The latter, via its activation domain, interacts with the conserved core of SAYP. STAT is associated with the SAYP-containing co-activator complex BTFly and recruits BTFly onto genes. SAYP is necessary for stimulating STAT-driven transcription of numerous genes. Mutation of SAYP leads to maldevelopments similar to those observed in STAT mutants. Thus, SAYP is a novel co-activator mediating the action of STAT.

SUBMITTER: Panov VV

PROVIDER: S-EPMC3315317 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Transcription co-activator SAYP mediates the action of STAT activator.

Panov Vladislav V VV Kuzmina Julia L JL Doronin Semen A SA Kopantseva Marina R MR Nabirochkina Elena N EN Georgieva Sofia G SG Vorobyeva Nadezhda E NE Shidlovskii Yulii V YV

Nucleic acids research 20111128 6

Jak/STAT is an important signaling pathway mediating multiple events in development. We describe participation of metazoan co-activator SAYP/PHF10 in this pathway downstream of STAT. The latter, via its activation domain, interacts with the conserved core of SAYP. STAT is associated with the SAYP-containing co-activator complex BTFly and recruits BTFly onto genes. SAYP is necessary for stimulating STAT-driven transcription of numerous genes. Mutation of SAYP leads to maldevelopments similar to t ...[more]

PMID: 22123744

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