Ontology highlight
ABSTRACT:
SUBMITTER: Tang H
PROVIDER: S-EPMC3315598 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Tang Hao H de Oliveira Carla Santos CS Sonntag Gage G Gibb Corinne L D CL Gibb Bruce C BC Bohne Cornelia C
Journal of the American Chemical Society 20120319 12
Water-soluble octaacid cavitands (OAs) form dimeric capsules suitable for guest incorporation. Our studies reveal that the mechanism of pyrene (Py) binding involves the rapid (<1 ms) formation of the Py·OA complex followed by slower binding with the second OA. The dissociation of the capsular OA·Py·OA complex occurs with a lifetime of 2.7 s, which is 5 orders of magnitude slower than the microsecond opening/closing ("breathing") previously observed to provide access of small molecules to the enc ...[more]