Ontology highlight
ABSTRACT:
SUBMITTER: Heun R
PROVIDER: S-EPMC3316448 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Heun Reinhard R Kölsch Heike H Ibrahim-Verbaas Carla A CA Combarros Onofre O Aulchenko Yurii S YS Breteler Monique M Schuur Maaike M van Duijn Cornelia M CM Hammond Naomi N Belbin Olivia O Belbin Olivia O Cortina-Borja Mario M Wilcock Gordon K GK Brown Kristelle K Barber Rachel R Kehoe Patrick G PG Coto Eliecer E Alvarez Victoria V Lehmann Michael G MG Deloukas Panos P Mateo Ignacio I Morgan Kevin K Warden Donald R DR Smith A David AD Lehmann Donald J DJ
International journal of molecular epidemiology and genetics 20120223 1
<h4>Objective</h4>Neuroinflammation contributes to the pathogenesis of sporadic Alzheimer's disease (AD). Variations in genes relevant to inflammation may be candidate genes for AD risk. Whole-genome association studies have identified relevant new and known genes. Their combined effects do not explain 100% of the risk, genetic interactions may contribute. We investigated whether genes involved in inflammation, i.e. PPAR-α, interleukins (IL) IL- 1α, IL-1β, IL-6, and IL-10 may interact to increas ...[more]