Crystal structure of Streptococcus pyogenes Csn2 reveals calcium-dependent conformational changes in its tertiary and quaternary structure.
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ABSTRACT:
SUBMITTER: Koo Y
PROVIDER: S-EPMC3316568 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Crystal structure of Streptococcus pyogenes Csn2 reveals calcium-dependent conformational changes in its tertiary and quaternary structure.
Koo Yoon Y Jung Du-kyo DK Bae Euiyoung E
PloS one 20120330 3
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins constitute a microbial immune system against invading genetic elements, such as plasmids and phages. Csn2 is an Nmeni subtype-specific Cas protein, and was suggested to function in the adaptation process, during which parts of foreign nucleic acids are integrated into the host microbial genome to enable immunity against future invasion. Here, we report a 2.2 Å crystal structure of Streptococcu ...[more]
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