The abundance of deleterious polymorphisms in humans.
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ABSTRACT:
SUBMITTER: Subramanian S
PROVIDER: S-EPMC3316666 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in humans. ...[more]
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2024-06-11 | GSE252791 | GEO
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