Ontology highlight
ABSTRACT:
SUBMITTER: Hudson JJ
PROVIDER: S-EPMC3316882 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Nature communications 20120313
Breaking and sealing one strand of DNA is an inherent feature of chromosome metabolism to overcome torsional barriers. Failure to reseal broken DNA strands results in protein-linked DNA breaks, causing neurodegeneration in humans. This is typified by defects in tyrosyl DNA phosphodiesterase 1 (TDP1), which removes stalled topoisomerase 1 peptides from DNA termini. Here we show that TDP1 is a substrate for modification by the small ubiquitin-like modifier SUMO. We purify SUMOylated TDP1 from mamm ...[more]