Ontology highlight
ABSTRACT:
SUBMITTER: Freitas-Andrade M
PROVIDER: S-EPMC3318143 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Freitas-Andrade Moises M Carmeliet Peter P Charlebois Claudie C Stanimirovic Danica B DB Moreno Maria J MJ
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20111130 4
In this study, we have investigated the potential role of placental growth factor (PlGF) in hypoxia-induced brain angiogenesis. To this end, PlGF wild-type (PlGF(+/+)) and PlGF knockout (PlGF(-/-)) mice were exposed to whole body hypoxia (10% oxygen) for 7, 14, and 21 days. PlGF(+/+) animals exhibited a significant ~40% increase in angiogenesis after 7 days of hypoxia compared with controls, while in PlGF(-/-) this effect only occurred after 14 days of hypoxia. No differences in pericyte/smooth ...[more]