Ontology highlight
ABSTRACT:
SUBMITTER: de Zubiria Salgado A
PROVIDER: S-EPMC3318208 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
de Zubiria Salgado Alberto A Herrera-Diaz Catalina C
Autoimmune diseases 20120322
Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a result of an amplified epitope immunological response. IC glomerular deposits generate release of proinflammatory cytokines and cell adhesion molecules causing inflammation. This leads to monocytes an ...[more]