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Dissemination of the fosfomycin resistance gene fosA3 with CTX-M ?-lactamase genes and rmtB carried on IncFII plasmids among Escherichia coli isolates from pets in China.

ABSTRACT: The presence and characterization of plasmid-mediated fosfomycin resistance determinants among Escherichia coli isolates collected from pets in China between 2006 and 2010 were investigated. Twenty-nine isolates (9.0%) were positive for fosA3, and all of them were CTX-M producers. The fosA3 genes were flanked by IS26 and were localized on F2:A-:B- plasmids or on very similar F33:A-:B- plasmids carrying both bla(CTX-M-65) and rmtB. These findings indicate that the fosA3 gene may be coselected by antimicrobials other than fosfomycin.

SUBMITTER: Hou J

PROVIDER: S-EPMC3318358 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Dissemination of the fosfomycin resistance gene fosA3 with CTX-M β-lactamase genes and rmtB carried on IncFII plasmids among Escherichia coli isolates from pets in China.

Hou Jianxia J Huang Xianhui X Deng Yuting Y He Liangying L Yang Tong T Zeng Zhenling Z Chen Zhangliu Z Liu Jian-Hua JH

Antimicrobial agents and chemotherapy 20120109 4

The presence and characterization of plasmid-mediated fosfomycin resistance determinants among Escherichia coli isolates collected from pets in China between 2006 and 2010 were investigated. Twenty-nine isolates (9.0%) were positive for fosA3, and all of them were CTX-M producers. The fosA3 genes were flanked by IS26 and were localized on F2:A-:B- plasmids or on very similar F33:A-:B- plasmids carrying both bla(CTX-M-65) and rmtB. These findings indicate that the fosA3 gene may be coselected by ...[more]

PMID: 22232290

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F33:A-:B- and F2:A-:B- plasmids mediate dissemination of rmtB-blaCTX-M-9 group genes and rmtB-qepA in Enterobacteriaceae isolates from pets in China.

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