Ontology highlight
ABSTRACT:
SUBMITTER: Chin MH
PROVIDER: S-EPMC3319057 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Chin Mark H MH Qian Wei-Jun WJ Wang Haixing H Petyuk Vladislav A VA Bloom Joshua S JS Sforza Daniel M DM Laćan Goran G Liu Dahai D Khan Arshad H AH Cantor Rita M RM Bigelow Diana J DJ Melega William P WP Camp David G DG Smith Richard D RD Smith Desmond J DJ
Journal of proteome research 20080201 2
The molecular mechanisms underlying the changes in the nigrostriatal pathway in Parkinson's disease (PD) are not completely understood. Here, we use mass spectrometry and microarrays to study the proteomic and transcriptomic changes in the striatum of two mouse models of PD, induced by the distinct neurotoxins 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and methamphetamine (METH). Proteomic analyses resulted in the identification and relative quantification of 912 proteins with two or mo ...[more]