Ontology highlight
ABSTRACT:
SUBMITTER: Veerasamy N
PROVIDER: S-EPMC3319147 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Veerasamy Nagarathanam N Carlson Erik C EC Carter Rich G RG
Organic letters 20120228 6
An efficient enantioselective synthesis of cermizine D has been developed that exploits the use of a common intermediate to access over 85% of the carbon backbone. Key steps include an organocatalyzed heteroatom Michael addition, a diastereoselective alkylation with α-iodomethyl phenyl sulfide, a conjugate addition to a vinyl sulfone species, and a sulfone coupling/desulfurization sequence to join the two major subunits. ...[more]