Dataset Information

Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility.

ABSTRACT:

Objective

To identify risk factors for pregnancy outcomes in couples treated with intracervical or intrauterine insemination, with or without superovulation for unexplained or male-factor infertility.

Design

Secondary analysis of data from a randomized superovulation and intrauterine insemination trial.

Setting

Academic medical centers.

Intervention(s)

Treatment continued for four cycles unless pregnancy was achieved.

Patient(s)

Out of 932 couples randomized to four treatment groups, 664 couples who had completed the lifestyle questionnaires were assessed for occurrence of pregnancy and live birth.

Main outcome measure(s)

Pregnancy and live birth.

Result(s)

The pregnancy and live birth rates were significantly higher in couples in which the female partners reported that they had consumed coffee or tea in the past or drank alcoholic beverages in the past (past users) compared with those who had never consumed coffee, tea, or alcoholic beverages. Past users also had significantly higher pregnancy and live birth rates than those currently consuming coffee or tea or alcoholic beverages. Demographic, occupational exposure, and other lifestyle factors were not significant.

Conclusion(s)

Couples in which the female partners drank coffee, tea, or alcoholic beverages in the past had higher pregnancy and live birth rates compared with never or current users. When discontinuing these habits, they might have made other lifestyle changes to improve the pregnancy outcome.

SUBMITTER: Huang H

PROVIDER: S-EPMC3319287 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility.

Huang Hao H Hansen Karl R KR Factor-Litvak Pamela P Carson Sandra A SA Guzick David S DS Santoro Nanette N Diamond Michael P MP Eisenberg Esther E Zhang Heping H

Fertility and sterility 20120123 4

<h4>Objective</h4>To identify risk factors for pregnancy outcomes in couples treated with intracervical or intrauterine insemination, with or without superovulation for unexplained or male-factor infertility.<h4>Design</h4>Secondary analysis of data from a randomized superovulation and intrauterine insemination trial.<h4>Setting</h4>Academic medical centers.<h4>Intervention(s)</h4>Treatment continued for four cycles unless pregnancy was achieved.<h4>Patient(s)</h4>Out of 932 couples randomized t ...[more]

PMID: 22270557

Similar Datasets

Project description:BackgroundFew studies have described the relationship between the type of infertility and live birth in patients treated with intrauterine insemination (IUI). We focused on this issue and attempted to explore it.MethodsThis retrospective study enrolled 2,256 infertile patients who underwent their first IUI cycle and were subsequently diagnosed with a clinical pregnancy at Ji'an Women and Child Health Care Hospital between 2007 and 2018. Inductees were divided into primary infertility (1,680 patients) and secondary infertility groups (876 patients). Following 1:1 propensity score matching to obtain balanced data, the COX proportional hazards model, landmark analysis, and subgroup analysis were used to assess the association between infertility types and live birth rates. Subsequently, a sensitivity analysis was employed to evaluate the potential effect of unmeasured confounding on outcomes.ResultsOf the 1,486 patients who were identified as a matched cohort, 743 were in the primary infertility group and the remaining patients were in another group. A total of 1,143 patients had live births during 431,009 person-days of follow-up (average 290.0 days). Throughout the follow-up period, patients with secondary infertility demonstrated more live births than patients with primary infertility (hazard ratio [HR], 1.16; 95% confidence interval [CI], 1.04 to 1.30; P = .007). More details were observed in the landmark analysis. Live birth rates were similar in both groups within 316 days of follow-up (HR, 0.84; 95% CI, 0.62 to 1.14; P = .269), whereas the opposite was found between 316 days of follow-up and delivery day (HR, 1.19; 95% CI, 1.06 to 1.34; P = .004). This was also obtained in a subgroup analysis of patients younger than 35 years old and patients treated with natural cycles (NCs) and IUIs.ConclusionAmong the infertile patients who underwent a single natural or stimulated cycle followed by IUI and had later pregnancies, full-term young secondary infertility mothers (<35 years of age) had a greater chance of having viable babies than the primary infertility ones. The latter may get more benefits when undergoing ovarian stimulation and IUI rather than NC-IUI.

Dataset Information

Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility.

Objective

Design

Setting

Intervention(s)

Patient(s)

Main outcome measure(s)

Result(s)

Conclusion(s)

Publications

Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility.

Similar Datasets

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