Ontology highlight
ABSTRACT:
SUBMITTER: Tradtrantip L
PROVIDER: S-EPMC3319430 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Tradtrantip Lukmanee L Sonawane N D ND Namkung Wan W Verkman A S AS
Journal of medicinal chemistry 20091001 20
Inhibitors of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel are predicted to slow cyst enlargement in polycystic kidney disease and reduce intestinal fluid loss in secretory diarrheas. Screening of approximately 110000 small synthetic and natural compounds for inhibition of halide influx in CFTR-expressing epithelial cells yielded a new class of pyrimido-pyrrolo-quinoxalinedione (PPQ) CFTR inhibitors. Testing of 347 analogues established structure-activity relat ...[more]