Ontology highlight
ABSTRACT:
SUBMITTER: McCreedy DA
PROVIDER: S-EPMC3319638 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
McCreedy Dylan A DA Rieger Cara R CR Gottlieb David I DI Sakiyama-Elbert Shelly E SE
Stem cell research 20111213 3
Embryonic stem cells (ESCs) hold great potential for replacing neurons following injury or disease. The therapeutic and diagnostic potential of ESCs may be hindered by heterogeneity in ESC-derived populations. Drug selection has been used to purify ESC-derived cardiomyocytes and endothelial cells but has not been applied to specific neural lineages. In this study we investigated positive selection of progenitor motor neurons (pMNs) through transgenic expression of the puromycin resistance enzyme ...[more]