The many roles of TOX in the immune system.
Ontology highlight
ABSTRACT:
SUBMITTER: Aliahmad P
PROVIDER: S-EPMC3319641 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
The many roles of TOX in the immune system.
Aliahmad Parinaz P Seksenyan Akop A Kaye Jonathan J
Current opinion in immunology 20111230 2
TOX is a member of an evolutionarily conserved DNA-binding protein family and is expressed in several immune-relevant cell subsets. Here, we review the key role of TOX in regulating development of CD4 T cells, natural killer cells and lymphoid tissue inducer cells, the latter responsible for the generation of lymph nodes. Although the exact molecular mechanism of action of TOX remains to be elucidated, the role of TOX in establishment of gene programs in the thymus and the potential of TOX as a ...[more]
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