Ontology highlight
ABSTRACT:
SUBMITTER: Hayashi MT
PROVIDER: S-EPMC3319806 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Hayashi Makoto T MT Cesare Anthony J AJ Fitzpatrick James A J JA Lazzerini-Denchi Eros E Karlseder Jan J
Nature structural & molecular biology 20120311 4
Telomere shortening and disruption of telomeric components are pathways that induce telomere deprotection. Here we describe another pathway, in which prolonged mitotic arrest induces damage signals at telomeres in human cells. Exposure to microtubule drugs, kinesin inhibitors, proteasome inhibitors or the disruption of proper chromosome cohesion resulted in the formation of damage foci at telomeres. Induction of mitotic telomere deprotection coincided with dissociation of TRF2 from telomeres, te ...[more]