Ontology highlight
ABSTRACT:
SUBMITTER: Muller-Quernheim UC
PROVIDER: S-EPMC3319930 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Müller-Quernheim Ulrike Carolin UC Potthast Lars L Müller-Quernheim Joachim J Zissel Gernot G
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20120126 4
Tumor-associated macrophages infiltrate tumors and facilitate tumor growth. Here, we analyzed M1 and M2 marker expression in the course of co-culture-driven macrophage differentiation and investigated the influence of interferons (IFNs) on this differentiation. To generate monocyte-derived macrophages (MDMs) 1×10⁶ monocytes of healthy volunteers were cultivated either with 25×10³ adherent A549/mL or in medium containing 50% A549 conditioned medium (CM) for 72 h in the presence or absence of IFN- ...[more]